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For most patients, 2.5 mg once weekly is the recommended starting dose of tirzepatide

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Consequently, optimisation of nose-to-brain delivery is frequently achieved through a combination of targeted deposition in upper nasal regions and permeability-enhancing excipients as well as nanocarrier systems that protect the active pharmaceutical ingredient (API) from enzymatic degradation and facilitate mucosal transport (Chung et al., 2023, Dhuria et al., 2010, Illum, 2003)

95 , 37963800 (1991) Dolui, B.K., Bhattacharyya, S.K., Kundu, K.K.: Single-ion transfer Gibbs energies in binary mixtures of isodielectric protic ethylene glycol and dipolar aprotic N , N -dimethylformamide