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Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction

Interestingly, assessment of binding properties in a hemi-equilibrium membrane binding assay revealed that OWL-833 had 10-fold higher affinity than PF 06882961 ( Figures 1H & S1G ), suggesting that while the two agonists have similar concentration response profiles in cAMP accumulation ( Figure 1B ), PF 06882961 has higher efficacy for this pathway