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Instead of building a drug against a known mutation and hoping the drug will be effective for others, we use multiplexing to a-priori identify molecules that are effective against as many of the mutations as possible (Figure 2)

Blood IGF1 levels of the rhGH rats were not different significantly from those of the control rats on PND 24 or 31

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Of note, Glp1r-expressing neurons are all labeled in the Phox2b-Cre-tdTomato mouse model (Supplementary Fig