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HDAC inhibitors are classified into four main subgroups based on their chemical composition: hydroxamic acids, benzamides, cyclic tetrapeptides, and short-chain fatty acids ( Table 2 ) ( Table 2 Introduction to the mechanism of action, trial phase, and FDA approval of HDACi

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Symptoms of folate deficiency include poor growth, tongue inflammation, gingivitis, loss of appetite, shortness of breath, diarrhoea, irritability, forgetfulness, and mental sluggishness

it is precursor evidence, not direct evidence for the marketed compound