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Mechanistically, CUR triggered ferroptosis in osteosarcoma cells by regulation of the Nrf2/GPX4 signaling pathway (100)

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The succinylation of PGK1 disrupts the integrity of the blood-brain barrier by modulating the angiostatin/VEGF pathway, leading to alterations in seizure activity (183)

By limiting this pathway, it reduces the flood of inflammatory cytokines that can damage tissues.8 Protecting mitochondria and preventing excess cell death TUDCA stabilizes mitochondria, the cells energy producers, so they keep working under stress