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The most commonly reported side effects include: Nausea and vomiting particularly during dose escalation Diarrhoea or constipation affecting bowel regularity Abdominal pain and bloating related to delayed gastric emptying Dyspepsia indigestion or upper abdominal discomfort Headache especially during initial treatment Fatigue and dizziness especially in the initial treatment phase Injection site reactions such as redness or irritation These gastrointestinal effects typically diminish over time as the body adjusts to the medication

These symptoms may indicate advanced liver disease or complications requiring urgent assessment and specialist referral

Protecting the Intestinal Barrier Your gut lining is composed of a single layer of cells called enterocytes, which are held together by "tight junctions." These junctions act like a gatekeeper, ensuring that nutrients pass through while keeping undigested food particles and harmful microbes out

Potential effects on food reward pathways reduce hedonic eating