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However, pathologic conditions activate microglia to increase cytokine production, resulting in either a pro-inflammatory or anti-inflammatory phenotype, classically defined as M1 and M2, respectively, (Woodburn et al., 2021

Paton, J

In an extreme example, the Aral Sea in Central Asia has decreased to only 10% of its initial size after water was diverted for agriculture (see this case study for more details)

Nonetheless, more longitudinal and adequately powered studies are needed to determine their long-term efficacy on cognitive trajectories in this population