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This rapid glucose lowering can also induce hypoxia, which may modulate the effect of GLP-1 RAs on retinal VEGF expression [100]

Despite being a therapeutic approach that the FDA has not approved, numerous patients experiences have shown it to be safe

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HFD impairs liver glutathione biosynthesis, vitamin D metabolism genes and genes associated with non-alcoholic fatty liver disease (NAFLD) Genes involved in the GSH biosynthesis pathway were significantly downregulated in the livers of mice fed an HFD compared to those of mice fed a healthy diet (controls) (Fig