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BSA was procured from Fisher BioReagents (Pittsburgh, PA, USA), and the rest of the reagents were procured from Sigma-Aldrich (Numbrecht, Germany/Saint Louis, MO, USA)

The Phase 2 trial reported small increases in heart rate (around 6.7 beats per minute at 12 mg), peaking around week 24 and then declining

But the durable outcomes still come from rebuilding the soil: nutrition quality, muscle mass, sleep, stress biology, environment, and behavior loops

This dual mechanism enhances insulin secretion and reduces hyperglycemia more effectively than treatments targeting only the GLP-1 receptor, contributing to significant weight loss and improved metabolic health