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The clock starts ticking immediately upon reconstitution, and room temperature storage accelerates the countdown dramatically

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doi: 10.1080/20013078.2020.1735249 118 HanYZhangYYPanYQZhengXJLiaoKMoHYet al

Interestingly, genetic mouse models of heart-specific CPT I deletion exhibit significant left ventricular systolic dysfunction in response to pressure overload that exacerbates progressively with duration of CPT I gene knockout ( in vivo mechanical deficit induced by chronic CPT I inhibition is paralleled by marked ventricular hypertrophy and an increased susceptibility to premature death (Zhang et al., 2016)