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Recent studies also suggest that curcumin upregulates long noncoding RNA growth arrest-specific transcript 5 (GAS5), which activates the brain-derived neurotrophic factor (BDNF)/TrkB signaling pathway to promote synaptic protein expression

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Though further large-scale studies are needed, the early evidence supporting peptides and supplements is compelling, especially when these tools are used in conjunction with evidence-based treatments such as behavioral therapy and medication-assisted treatment