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Recently, it was demonstrated that ferroptosis blockade significantly improved the estrous cycle disorder and prolonged the estrous cycle of primary ovarian aging by intraperitoneal injection of Fer-1 in Bnc1 mutant mice, and the ratio of oxidized to reduced lipids in the ovary was significantly reduced

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[2] It is usually administered by a nasogastric tube into the stomach as the thick slurry required for maximum adsorption is very difficult to swallow

(10 g or 10 ng/kg/day), topical (1.0 g in cream), or per-oral (0.16 g/mL in drinking water) over 90 days and described directional improvements across biomechanical, functional, macroscopic, and histological endpoints, though specific effect sizes and p-values are not reported in the abstract