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471 Knocking down FTH in cardiomyocytes prevents free iron from being stored in ferritin, increases unstable iron pools, promotes intracellular ROS production, activates oxidative stress, and causes ferroptosis in cardiomyocytes, leading to age-related heart damage
While tirzepatide does not directly cause thyroid dysfunction, weight loss and metabolic changes can sometimes unmask subclinical thyroid disease
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