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Renal diseases generally lead to L-carnitine homeostasis imbalance as long-term hemodialysis leads to an increase in the ratio of L-AC to free L-carnitine

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The SGLT2i treated cohort showed preservation of eGFR over a 5-year period compared with the GLP-1 RA treated cohort (+3.5 ml/min per 1.73 m 2 vs 7.2 ml/min per 1.73 m 2 , respectively), including patients with established chronic kidney disease (CKD)

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Hypertension 73 , 522531 (2019)

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