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Linear mixed-effects models were applied to manage random effects from biological variability across subjects and repeated measurements, incorporating fixed effects (treatment, time, and their interaction) and random effects (individual variability)

Researchers speculated that the benefits of thiamine may arise from improvements in energy metabolism in surviving dopaminergic neurons in the substantia nigra

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recently proved that treatment with GDF15 ameliorated insulin sensitivity independently of weight loss in mice and rats [63]