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Novel expression of multiple markers for ROS and apoptosis in differentiating inner root sheath (IRS) of anagen scalp hair follicles A striking feature of this study was the intense but highly nuanced expression of markers for ROS and apoptosis/(terminal) differentiation in the IRS (supplementary figures 3af), including Caspase-2 (CASP-2) and Caspase-9 (CASP-9), (supplementary figures 3a and 3b respectively), the DNA damage marker GADD45 (supplementary figure 3c), p21 (supplementary figure 3d), p57 and phospho-p57 (supplementary figure 3e), GR-1 (supplementary figure 3f.) and HO-1 (supplementary figures 3g and 3h)

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This approval followed successful SURMOUNT clinical trials demonstrating 1522% weight loss over 72 weeks