Enzymes such as Dipeptidyl Peptidase-4 (DPP-4) and Neutral Endopeptidase (NEP) contribute to this process, yielding inactive biological fragments (23)(30) Semaglutide, Serum, and tissue proteases metabolize the polypeptide into amino acids, clearing it from the system and preventing accumulation (23)(21)
In addition to weight reduction, which may increase with longer treatment duration, GIP agonism appears to enhance insulin sensitivity, blood flow, and adipose tissue storage capacity32 (Table 2)
These cumulative effectsreduced responsiveness, immune modulation, and disturbed melanocytekeratinocyte interactionscontribute to an increased susceptibility of melanocytes to UV-induced oxidative damage and highlight the need for targeted protective strategies
The role of a DPP-4 inhibitor is long-term glucose support, not rapid correction of an urgent problem