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Cells with impaired PERK-eIF2a-ATF4 signal transduction are more sensitive to hypoxic stress in vitro , indicating that the PERK-eIF2a-ATF4 pathway provides a survival advantage for cells under hypoxic conditions (75, 76), which is crucial for resistance to intracellular hypoxia, metabolic stress, and starvation
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Extreme temperatures further limit electron transport and enzymatic activity: cold reduces membrane fluidity and inhibits chloroplast biogenesis, whereas heat accelerates protein denaturation (Zhang et al
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