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In the STEP-1 trial, participants taking semaglutide 2.4 mg weekly (Wegovy) lost an average of 14.9% of their body weight over 68 weeks, with significant reductions in waist circumference averaging 13.5 cm (about 5.3 inches)

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Under heat stress stimulation in both in vivo mouse models and in vitro cell experiments, the transport of p53 protein from the nucleus to the cytoplasm increases significantly, where it binds to Parkin protein, reducing Parkin's translocation from the cytoplasm to mitochondria