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2 pmol of MT2 in 50 mM ammonium acetate were injected, desalted on-system, and a five minute 1580% B linear gradient was applied for sample separation on a nanoEase M/Z BEH C4 300 , 5 m, 300 m 50 mm column (Waters), which was kept at 80 C

The mechanistic rationale is strong, the safety profile is established, and the observation that psoriatic arthritis patients have lower thymosin alpha-1 levels is suggestive

[2] That combination of magnitude and momentum is what generated the intense interest in retatrutide as a potential next step beyond dual agonism