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Severe effects requiring emergency medical attention include severe abdominal pain, yellowing of skin or eyes, swelling of face or throat, difficulty breathing, fainting, or vision changes

Studies in rodents and primates have signaled that GLP-1 agonists may drive a reduction in intake of alcohol and drugs of abuse, and clinical trials have been initiated to investigate whether preclinical findings can be translated to humans

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When looking at specific mental health conditions, semaglutide use was linked to significantly lower risks of worsening depression, anxiety, and substance use disorders