fda safety communication semaglutide naion 2025 GLP-1 Receptor Agonists and vision risk The obesity drug semaglutide (Wegovy)

2023 Jul 12;28(14):5363

Since Semaglutide GLP-1 has a longer half-life than liraglutide, it can be given infrequently in comparison (once weekly for Semaglutide GLP-1 vs

Abbreviations AACE: American Association of Clinical Endocrinology AE: Adverse event CDS: Chinese Diabetes Society DPP-4i: Dipeptidyl peptidase-4 inhibitor ETD: Estimated treatment difference FPG: Fasting plasma glucose GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist PIONEER: Peptide Innovation for Early Diabetes Treatment SAE: Serious adverse event SF-36v2: 36-item Short Form Health Survey (Acute Version) SMPG: Self-monitored plasma glucose References Sun H, Saeedi P, Karuranga S et al (2022) IDF diabetes atlas: global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045

Their primary function is to stimulate insulin secretion, but they do more than that, and the full scope of what they do is central to understanding why GLP-1 receptor agonists have become so significant in clinical practice