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Transdermal-specific considerations for patches would include: Local skin reactions (erythema, itching, irritation at application site) Contact dermatitis from adhesive components or penetration enhancers Skin integrity concerns requiring regular site rotation Patient safety advice for anyone using GLP-1 therapy includes: Report persistent severe abdominal pain (potential pancreatitis) Monitor for signs of gallbladder problems (right upper quadrant pain, particularly after meals) Maintain adequate hydration, especially if experiencing vomiting or diarrhoea Contact your GP if side effects are severe, persistent, or concerning Report suspected side effects via the MHRA Yellow Card scheme (yellowcard.mhra.gov.uk) Regarding pregnancy and breastfeeding, advice varies by product

A review of small-molecule inhibitors of one-carbon enzymes: SHMT2 and MTHFD2 in the spotlight

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