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Clinical Endocrinology , 35(4), 405-415

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The microdose strategy reflects emerging clinical data showing that lower-concentration GLP-1 exposures can produce meaningful weight loss in responsive patients while dramatically reducing nausea, vomiting, and constipation

However, there is a small problem with being able to achieve this through supplementation: synthetic forms are poorly bioavailable , that is, the body cannot take advantage of them in its processes, and thus the benefits of external supply are negated