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Antioksidan oral seperti vitamin C, vitamin E , asam traneksamat , flavonoid, dan berbagai ekstrak botanical sudah dicoba untuk menangani melasma dan gangguan hiperpigmentasi , tapi belum terbukti memberikan efek pencerah kulit secara keseluruhan

The mechanism involves stimulation of gastric contractility through ghrelin receptor-mediated pathways located on cholinergic excitatory neurons

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Mol Metab 20 , 5162 (2019)