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In clinical trials of semaglutide injection for weight management, acute pancreatitis was confirmed by adjudication in 4 semaglutide-treated patients (0.2 cases per 100 patient-years) versus 1 in placebo-treated patients (less than 0.1 cases per 100 patient-years)

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Vitamin B6-dependent epilepsy is a group of autosomal recessive disorders caused by mutations in the genes for phosphatidylinositol binding protein (PLPBP), acetaldehyde dehydrogenase 4 family member A1 (ALDH4A1), acetaldehyde dehydrogenase 7 family member A1 (ALDH7A1), pyridoxal (amine) 5'-phosphate oxidase (PNPO), and tissue non-specific alkaline phosphatase (TNSALP)