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Mechanistic link between vitamin B12 and alzheimers disease

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doi: 10.1038/s41563-018-0028-2 420 HuaiYZhangYXiongXDasSBhattacharyaRMukherjeeP

The sensorium is clear in the beginning, but it often evolves into the syndrome of DT, a specific type of delirium typically associated with psychomotor agitation (hyperactive delirium) which emerges during the late withdrawal phase.14, 18 Delirium can also manifest as a hypoactive state with decreased arousal and psychomotor activity, which is associated with a worse prognosis, delayed diagnosis and treatment as well as later complications.6 In cases of hypoactive delirium, comorbid or other medical illnesses must be ruled out