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However, GSTs cannot participate in the direct metabolism of pyrethroid insecticides, whereas they may mediate insect resistance to pyrethroid insecticides by detoxifying lipid peroxidation products induced by pyrethroids [9]

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Regulatory and compounding status All four compounds share a broadly similar regulatory landscape in the United States as of 2026: None are FDA-approved as finished drug products for therapeutic use All are classified as WADA S2 prohibited substances year-round All four have 503A compounding status of Under Review, meaning the FDA Pharmacy Compounding Advisory Committee (PCAC) has nominated them for evaluation but final category assignments (Category 1 permitted for compounding

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