Moreover, we retrieved other relevant records 56,57,58 : two large ( N = 133,318 and N = 342,608, respectively) cohort studies in people with diabetes across 613 years noted a beneficial association between GLP-1RA prescriptions compared with non-prescription and lower diagnoses of dementia 57,58 , while a small ( N = 154 patients with T2DM) and shorter (~12 months) cross-sectional investigation of GLP-1RAs in addition to metformin, compared with metformin alone, observed better MoCA scores in the former group 56
One concern rising to the surface is their effect on muscle mass, the true "organ of longevity." Losing muscle isn't just about aesthetics, however
Leaderboards that refresh frequently, achievement badges, and gentle nudges about newly released titles keep the experience feeling current without being pushy
There are scattered reports of hormonal and mood effects, though the research here is limited