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These diverse therapeutic effects of semaglutide raise a vital mechanistic question, namely whether these effects align along a single axis, or whether the drug provides separable cardiovascular benefits that are independent of the magnitude of weight reduction achieved

The medication is administered subcutaneously once weekly and reaches steady-state concentrations after 45 weeks of treatment, according to the Wegovy Summary of Product Characteristics (SmPC)

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For procedures in which complications are catastrophic, including TJA, counseling should prioritize discontinuation of nonessential injectable biologics before surgery, explicit documentation of exposure, and heightened vigilance for early wound complications