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We interrogated publicly available single cell RNA sequencing (scRNA-seq) datasets to identify the specific cardiac cell types that express Glp1r / GLP1R

The drug targets three receptors involved in energy balance and metabolism: GLP-1 (glucagon-like peptide-1) receptor GIP (glucose-dependent insulinotropic polypeptide) receptor Glucagon receptor By activating these pathways, the therapy aims to: Reduce appetite Improve insulin regulation Increase metabolic activity and energy expenditure This triple-receptor mechanism distinguishes retatrutide from earlier metabolic drugs that target only one or two pathways

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This goes beyond managing diabetes and obesity to include neurodegenerative diseases of the central nervous system