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The rectal route of administration can be particularly useful for patients who have difficulties with oral ingestion or for those who require a rapid onset of action

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[2] Vitamin B 2 was tentatively identified to be the factor necessary for preventing pellagra, but that was later confirmed to be due to niacin (vitamin B 3 ) deficiency

Mol Pharmacol 65:5507, PMID: 14978233 Coles BF, Kadlubar FF (2003) Detoxification of electrophilic compounds by glutathione S -transferase catalysis: determinants of individual response to chemical carcinogens and chemotherapeutic drugs