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(2006) characterized TREK-1 knockout mice and observed resistance to behavioral despair paradigms, elevated serotonin levels, and increased hippocampal neurogenesis, establishing the rationale for TREK-1 blockade [3]

intragastric strong alcohol severe stomach lesions) and adaptive cytoprotection concept ( severe stomach lesion reversed to mild stomach lesion

Pungent vanilloids such as capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), a major pungent of hot chili pepper ( Capsicum annuum ) [206, 223], and (10)-shogaol from ginger ( Zingiber officinale ) also activate phase II detoxification enzyme expression in a Nrf2-dependent manner [207]

That makes it endogenous , meaning naturally produced within