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Wang L , Wheeler DA, Prchal JT
After the employ of the ferroptosis inhibitor Lip-1, a significant decrease of LPO was found in JEV-infected SH-SY5Y cells, and viral titers and inflammation were reduced in JEV-infected mice ultimately improving the survival rate of infected mice (Zhu et al., 2024)
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However, excessive iron not only induces the peroxidation of lipids through the mediation of the Fenton reaction, but also acts as an essential cofactor for enzymes that participate in lipid peroxidation (such as ALOX and POR) ( 3+ is internalized and carried to endosomes by means of the transferrin receptor ( 3+ into Fe 2+ ( 2+ from endosomes into the cytoplasmic labile iron pool, serving as a source for the Fenton reaction (Yanatori and Kishi, 2019)
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