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The modest time savings (arriving at the maintenance dose two to four weeks earlier) does not offset the substantially worse side effect experience during those initial weeks

Tang A, Ng CH, Phang PH, Chan KE, Chin YH, Fu CE, et al

Last month Pfizer said treatment with a 120mg dose of danuglipron led to average weight loss of about 4.6 kilograms, or about 10 pounds, at week 16 of a Phase 2b trial

In soggetti con funzione renale fortemente compromessa o in dialisi, la somministrazione orale cronica di L-carnitina pu dare luogo ad accumulo di TMA e TMAO nel sangue con conseguente trimetilamminuria, condizione patologica caratterizzata da un forte "odore di pesce" presente nelle urine, nell'alito e nel sudore del paziente