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Topamax gained FDA approval in 1996 for the treatment of various forms of epilepsy, a neurological disorder characterized by recurrent, uncontrolled seizures

The Hansoh deal fits with Mercks strategy in obesity, which according to CEO Robert Davis will center on small molecule oral drugs rather than injectable peptide treatments

As a television show host, Oz spent years promoting various weight-loss drugs, including more recently, GLP-1 drugs

In the medication off state (12 h after medication withdrawal), five rsfMRI runs (6 min each, totalling 30 min) were acquired with a gradient-echo EPI sequence (TR = 3,000 ms, TE = 30 ms, flip angle = 90, voxel size = 3 3 3 mm 3 , 47 axial slices)