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The primary molecular actions relevant to skin are: modulation of TGF- signaling (upregulating TGF-1 for collagen I/III synthesis while suppressing TGF-2 to prevent scarring), decorin upregulation for orderly collagen fibril assembly, MMP suppression paired with TIMP upregulation to preserve ECM integrity, and copper-dependent lysyl oxidase activation for collagen crosslinking

An increase in daily running activity by 20% and an enlarged hippocampus were observed after the treatment with resveratrol (40 mg/kg p.o.) for 4-weeks

Combined with physical sun protection measures (e.g., sun-protective clothing, sun hats), it can significantly improve the protective effect