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Additional anti-inflammatory effects exerted by itaconate include activation of the basic region leucine zipper (bZIP) transcription factor identified as nuclear factor erythroid erythroid 2 ( N EF2)- r elated f actor 2 (NRF2)

Levocarnitine supplementation in nursing mothers has not been specificallystudied

PPARs as master regulators of carnitine homeostasis Genes regulated by peroxisome proliferator-activated receptor (PPAR) are involved in many biological processes such as fatty acid catabolism, ketogenesis and gluconeogenesis, and also play a key role in the regulation of carnitine homeostasis [189]

These findings suggest that GIP but not GLP-1RA may improve glucose disposal by ameliorating peripheral insulin sensibility and glucose utilization, while GIP added on to GLP-1RA may reduce food intake with a combined effect resulting in improvement of glucose control and weight loss