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doi: 10.1016/j.cmet.2017.07.011 27 SchmittCPortronAJadidiSSarkarNDiMarchiR

[DOI] [PMC free article] [PubMed] [Google Scholar] 6.Mechanisms mediating the diuretic and natriuretic actions of the incretin hormone glucagon-like peptide-1

Chronic mitochondrial ROS production in HF further drives myocyte apoptosis via ROS-mediated activation of caspases and mPTP opening, fibrosis through ROS-activated TGF- signaling in fibroblasts, and electrical instability due to oxidative damage to ion channels, increasing arrhythmia risk