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Citation36 Additionally, in combination therapies, determining the timing and synergy of different agents is complex

Allylamine Allylamines, such as naftifine, butenafine, and terbinafine, inhibit a flavine adenine dinucleotide dependent enzyme, squalene epoxidase (EC 1.14.99.7) [171], responsible for converting squalene to squalene-2,3-epoxide, an intermediate in the biosynthesis of lanosterol [163, 172]

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doi: 10.1146/annurev-biochem-061516-045037 8 SchieberMChandelNS