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A healthcare professional may recommend alternative diabetes or weight management treatments for people with: a personal or family history of thyroid cancer multiple endocrine neoplasia syndrome type 2 (MEN 2) a history of pancreatitis allergic reactions to Rybelsus or any of its components People with diabetic retinopathy, kidney issues, or a tendency for hypoglycemia (low blood sugar) may need careful monitoring while taking Rybelsus, too