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Doses used clinically generally start modestly and can be adjusted upward based on the patient, with the intravenous route favored precisely because it sidesteps the oral-absorption question

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Immunohistochemical analysis also revealed a significant decrease in the hepatic expression of both proapoptotic markers Bax and caspase-3 with significant increase in antiapoptotic Bcl-2 expression in rats treated with NTZ-200, NAC or 4-PBA when compared to MTX group (Figure 9)