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Plumbagin increased NAD(P)H quinone dehydrogenase 1 (NQO1) activity and decreased xCT expression, resulting in NQO1-dependent glioma cell death

PMID: 33157425 Hollinger A, von Felten S, Sutter R, Huber J, Tran F, Reinhold S, Abdelhamid S, Todorov A, Gebhard CE, Cajochen C, Steiner LA, Siegemund M (2020) Study protocol for a prospective randomised double-blind placebo-controlled clinical trial investigating a better outcome with melatonin compared to placebo administered to normalize sleep-wake cycle and treat hypoactive ICU delirium: the Basel BOMP-AID study

This is consistent with the idea that stabilization of structural plasticity induced by experience can take several hours to weeks, and involves both strengthening and weakening of selected synapses (Hofer et al., 2009

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