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While glutathione is a naturally occurring molecule in the body, it can interact with the way some medications are processed by the liver

In addition, due to its protein nature it is inactivated in the gastrointestinal tract, not being absorbed (practically null oral bioavailability), which hinders or prevents the passage into plasma of the infant from ingested breast milk (Serrano 2015), except in premature infants and during the immediate neonatal period, in which there may be greater intestinal permeability

MOTS-c is generally dosed once daily in the morning