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The major regulator of autophagy is the mechanistic (also known as mammalian) target of rapamycin (mTOR) signaling, which is closely associated with the activity of mitochondria

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Deferoxamine, the first FDA-approved drug in 1968 (Parker et al., 2023), is administered via intravenous (IV) or intramuscular (IM) injection due to its poor oral bioavailability, which is one of the most significant limitations of the DFO treatment (Entezari et al., 2022)

When the root of this nerve is compressed in your lower back, the resulting radiating numbness, tingling, or pain is called sciatica