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It has an essential role in energy production, DNA repair, and cellular regeneration

The cGASSTING pathway is emerging as a key inflammatory driver in this context, particularly when mitophagy fails to contain mitochondrial damage

Results Absence of promoter proximal NRF2 at NRF2 signature genes To identify critical pathways downstream of NRF2 activation in cancer, we sought to define a core set of genes and other features associated with NRF2-dependent growth across an expansive panel of cancer cell lines