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When a GLP-1 receptor agonist like semaglutide crosses the blood-brain barrier and binds to receptors in these reward centers, it appears to dampen the dopamine surge associated with alcohol consumption

It is a natural powerhouse molecule called glutathione

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However, GLP-1R agonists elicit nausea and vomiting 6,10 , and increase mean heart rate via directly stimulating sinoatrial node and enhancing sympathetic nervous system tone 10,11,12