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In the absence of Hippo-stimulating signals, the core Hippo kinase cascade is inactive and YES-associated protein (YAP)/Transcriptional coactivator with PDZ-binding motif (TAZ) translocate into the nucleus to associate with YAP/TAZ-transcriptional enhanced associate domain (TEAD) family DNA-binding proteins and co-activate transcriptional programs

From 2020 to 2024, the share of GLP-1 initiation among patients newly diagnosed with PMOS who did not have type 2 diabetes increased from 1.1% to 7.3%