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Semaglutide is a GLP-1 analogue with an Aib (2-amino isobutyric acid) in position 2 and a C18 chain linked to K20 through a small PEG spacer which was accepted by the FDA in 2018 for the treatment of diabetes as a once weekly treatment and is presently in phase 3 clinical trial for a once daily oral treatment 50,51

[1] Additionally, patients taking insulin or sulfonylureas alongside GLP-1 receptor agonists may experience hypoglycemia, which can produce symptoms (tremor, palpitations, sweating) that mimic anxiety