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These drugs reduce appetite and caloric intake, but without resistance training and adequate protein intake, a meaningful portion of the weight lost can come from lean muscle mass rather than fat

The ongoing clinical trials of oral SERDs primarily focus on identifying subpopulations with potential benefits following CDK4/6 inhibitor failure, investigating the efficacy of SERDs in combination with CDK4/6 inhibitors as first-line therapy, and reducing mortality rates among high-risk populations during the adjuvant stage